Weight Change Alters the Small RNA Profile of Urinary Extracellular Vesicles in Obesity.

ABSTRACT:

Introduction

Various kidney diseases reportedly show different urinary extracellular vesicle (EV) RNA profiles. Although obesity is one of the main causes of chronic kidney disease, the expression pattern of urinary EV RNA in obesity is uncertain. Our aim was to sequence the small RNA profiles of urinary EVs in obese patients before and after weight reduction and compare them to those of healthy volunteers (HVs).

Methods

We recruited age-sex-matched obese patients and HVs. The small RNA profiles of urinary EVs were analyzed using RNA sequencing. To evaluate the effect of weight reduction, small RNA profiles of urinary EVs 6 months after bariatric surgery were also analyzed.

Results

The proportion of urinary EVs transfer RNA and microRNA of obese patients differed from

SUBMITTER: Choi D 

PROVIDER: S-EPMC9021654 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature