Metabolic Regulation of Fibroblast Activation and Proliferation during Organ Fibrosis.

ABSTRACT:

Background

Activated fibroblasts are present in the injury response, tumorigenesis, fibrosis, and inflammation in a variety of tissues and myriad disease types.

Summary

During normal tissue repair, quiescent fibroblasts transform into a proliferative and contractile phenotype termed myofibroblasts and are then lost as repair resolves to form a scar. When excessive levels are reached, activated fibroblasts proliferate and produce large amounts of extracellular matrix, which accumulates in the interstitial space of different organs. This accumulation leads to fibrotic dysfunction and multiple-organ dysfunction syndrome. To date, there are limited effective treatments for these conditions. Cellular metabolism is the cornerstone of all biological activities. Emerging evidence sh

SUBMITTER: Wang S 

PROVIDER: S-EPMC9021660 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature