Quantitative serology for SARS-CoV-2 using self-collected saliva and finger-stick blood.

ABSTRACT: Convenient and widespread serology testing may alter the trajectory of the COVID-19 pandemic. This study seeks to leverage high-throughput, multiplexed serologic assays, which have been adopted as benchmarks for vaccine efficacy, to support large-scale surveys of SARS-CoV-2 immunity using finger-stick blood and/or saliva. Specifically, we optimized MSD's serology assays, which were analytically validated for serum, to test self-collected finger-stick blood and saliva samples to identify prior infection. We show that these assays can be used with FDA-registered specimen collection devices to obtain quantitative measurements for self-collected samples. First, we show that salivary antibodies are stable without refrigeration or preservatives for at least 5 days. We selected classification thr

SUBMITTER: Campbell C 

PROVIDER: S-EPMC9021827 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature