Prognostic Gene Expression Signature for Age-Related Hearing Loss.

ABSTRACT:

Background

Our study aimed to determine the pathological mechanism of presbycusis at the molecular level, and determine potential biomarkers for the same.

Methods

Differentially expressed genes (DEGs) for presbycusis were obtained by analyzing the microarray data sets (GSE6045 and GSE49543) downloaded from the Gene Expression Omnibus (GEO). Gene ontology (GO), Kyoto Encyclopedia of Genes and Genome (KEGG) pathway, and protein-protein interaction (PPI) network analyses, and Gene Set Enrichment Analysis (GSEA) were performed to analyze the biological functions, molecular pathways, autophagy-related molecular markers, and the immune microenvironment of the DEGs in presbycusis. Then the prognostic roles of the hub genes were analyzed and verified in vivo.

Results

I

SUBMITTER: Peng L 

PROVIDER: S-EPMC9021842 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature