Contribution of Pseudomonas aeruginosa Exopolysaccharides Pel and Psl to Wound Infections.

ABSTRACT: Biofilms are the cause of most chronic bacterial infections. Living within the biofilm matrix, which is made of extracellular substances, including polysaccharides, proteins, eDNA, lipids and other molecules, provides microorganisms protection from antimicrobials and the host immune response. Exopolysaccharides are major structural components of bacterial biofilms and are thought to be vital to numerous aspects of biofilm formation and persistence, including adherence to surfaces, coherence with other biofilm-associated cells, mechanical stability, protection against desiccation, binding of enzymes, and nutrient acquisition and storage, as well as protection against antimicrobials, host immune cells and molecules, and environmental stressors. However, the contribution of specific exopolysa

SUBMITTER: Fleming D 

PROVIDER: S-EPMC9021892 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature