Association Between Clinical Factors and Result of Immune Checkpoint Inhibitor Related Myasthenia Gravis: A Single Center Experience and Systematic Review.

ABSTRACT:

Background

Neurological immune-related adverse events (nirAEs) are rare toxicities of immune-checkpoint inhibitors (ICI). With the increase use of ICIs, incidence of nirAEs is growing, among which ICI related MG (irMG) is causing high fatality rate. Given the limited evidence, data from a large cohort of patients with irMG is needed to aid in recognition and management of this fatal complication.

Objective

This study aimed to summarize clinical characteristics of irMG and explore predictors of irMG clinical outcome.

Methods

We summarized our institution's patients who were diagnosed as irMG between Sep 2019 and Oct 2021. We systematically reviewed the literature through Oct 2021 to identify all similar reported patients who met inclusion criteria. As the control group

SUBMITTER: Shi J 

PROVIDER: S-EPMC9022009 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature