Mineralocorticoid Receptor Antagonism Prevents the Synergistic Effect of Metabolic Challenge and Chronic Kidney Disease on Renal Fibrosis and Inflammation in Mice.
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ABSTRACT:
SUBMITTER: Palacios-Ramirez R
PROVIDER: S-EPMC9022039 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
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Mineralocorticoid Receptor Antagonism Prevents the Synergistic Effect of Metabolic Challenge and Chronic Kidney Disease on Renal Fibrosis and Inflammation in Mice.
Palacios-Ramirez Roberto R Lima-Posada Ixchel I Bonnard Benjamin B Genty Marie M Fernandez-Celis Amaya A Hartleib-Geschwindner Judith J Foufelle Fabienne F Lopez-Andres Natalia N Bamberg Krister K Jaisser Frederic F
Frontiers in physiology 20220407
Obesity and/or metabolic diseases are frequently associated with chronic kidney disease and several factors associated with obesity may contribute to proteinuria and extracellular matrix production. Mineralocorticoid receptor antagonists have proven their clinical efficacy in diabetic kidney disease with preclinical data suggesting that they may also be efficient in non-diabetic chronic kidney disease associated to metabolic diseases. In the present study we developed a novel mouse model combini ...[more]
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2021-09-10 | PXD024102 | Pride