A Toolkit for Profiling the Immune Landscape of Pediatric Central Nervous System Malignancies.

ABSTRACT: The prognosis of pediatric central nervous system (CNS) malignancies remains dismal due to limited treatment options, resulting in high mortality rates and long-term morbidities. Immunotherapies, including checkpoint inhibition, cancer vaccines, engineered T cell therapies, and oncolytic viruses, have promising results in some hematological and solid malignancies, and are being investigated in clinical trials for various high-grade CNS malignancies. However, the role of the tumor immune microenvironment (TIME) in CNS malignancies is mostly unknown for pediatric cases. In order to successfully implement immunotherapies and to eventually predict which patients would benefit from such treatments, in-depth characterization of the TIME at diagnosis and throughout treatment is essential. In this

SUBMITTER: Rozowsky JS 

PROVIDER: S-EPMC9022116 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature