Modular and mechanistic changes across stages of colorectal cancer.

ABSTRACT:

Background

While mechanisms contributing to the progression and metastasis of colorectal cancer (CRC) are well studied, cancer stage-specific mechanisms have been less comprehensively explored. This is the focus of this manuscript.

Methods

Using previously published data for CRC (Gene Expression Omnibus ID GSE21510), we identified differentially expressed genes (DEGs) across four stages of the disease. We then generated unweighted and weighted correlation networks for each of the stages. Communities within these networks were detected using the Louvain algorithm and topologically and functionally compared across stages using the normalized mutual information (NMI) metric and pathway enrichment analysis, respectively. We also used Short Time-series Expression Miner (STEM) alg

SUBMITTER: Rahiminejad S 

PROVIDER: S-EPMC9022252 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature