The regulatory role of NAAG-mGluR3 signaling on cortical synaptic plasticity after hypoxic ischemia.

ABSTRACT:

Background

Synapses can adapt to changes in the intracerebral microenvironment by regulation of presynaptic neurotransmitter release and postsynaptic neurotransmitter receptor expression following hypoxic ischemia (HI) injury. The peptide neurotransmitter N-acetylaspartylglutamate (NAAG) exerts a protective effect on neurons after HI and may be involved in maintaining the function of synaptic networks. In this study, we investigated the changes in the expression of NAAG, glutamic acid (Glu) and metabotropic glutamate receptors (mGluRs), as well as the dynamic regulation of neurotransmitters in the brain after HI, and assessed their effects on synaptic plasticity of the cerebral cortex.

Methods

Thirty-six Yorkshire newborn pigs (3-day-old, males, 1.0-1.5 kg) were selected and

SUBMITTER: Li K 

PROVIDER: S-EPMC9022257 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature