A novel model of traumatic femoral head necrosis in rats developed by microsurgical technique.

ABSTRACT:

Background

Clinical angiography and vascular microperfusion confirmed that the femoral head retains blood supply after a collum femur fracture. However, no animal model accurately mimics this clinical situation. This study was performed to establish a rat model with retained viability of the femoral head and partial vasculature deprivation-induced traumatic caput femoris necrosis by surgery.

Methods

Thirty rats were randomly divided into three groups (n = 10 per group): normal group, sham-operated group (Control), and ischemic osteonecrosis group. The femoral head of the normal group of rats underwent a gross anatomy study and microangiography to identify femoral head blood supply. Microsurgical techniques were used to cauterize the anterior-superior retinacular vessels to i

SUBMITTER: Lv Y 

PROVIDER: S-EPMC9022312 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature