The retinal ganglion cell layer reflects neurodegenerative changes in cognitively unimpaired individuals.

ABSTRACT:

Background

To evaluate a wide range of optical coherence tomography (OCT) parameters for possible application as a screening tool for cognitively healthy individuals at risk of Alzheimer's disease (AD), assessing the potential relationship with established cerebrospinal fluid (CSF) core AD biomarkers and magnetic resonance imaging (MRI).

Methods

We studied 99 participants from the Valdecilla Study for Memory and Brain Aging. This is a prospective cohort for multimodal biomarker discovery and validation that includes participants older than 55 years without dementia. Participants received a comprehensive neuropsychological battery and underwent structural 3-T brain MRI, lumbar puncture for CSF biomarkers (phosphorylated-181-Tau (pTau), total Tau (tTau), beta-amyloid 1-42 (Aβ

SUBMITTER: Lopez-de-Eguileta A 

PROVIDER: S-EPMC9022357 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature