Reduction in the infection fatality rate of Omicron variant compared with previous variants in South Africa.

ABSTRACT:

Objective

The SARS-CoV-2 Omicron (B.1.1.529) variant has caused global concern. Previous studies have shown that the variant has enhanced immune evasion ability and transmissibility and reduced severity.

Methods

In this study, we developed a mathematical model with time-varying transmission rate, vaccination, and immune evasion. We fit the model to reported case and death data up to February 6, 2022 to estimate the transmissibility and infection fatality ratio of the Omicron variant in South Africa.

Results

We found that the high relative transmissibility of the Omicron variant was mainly due to its immune evasion ability, whereas its infection fatality rate substantially decreased by approximately 78.7% (95% confidence interval: 66.9%, 85.0%) with respect to previous

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9022446 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature