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Draft Genome Sequences of Sixteen Fluoroquinolone-Resistant Extraintestinal Escherichia coli Isolates from Human Patients.

ABSTRACT: We report here the draft genome sequences of 16 fluoroquinolone-resistant extraintestinal Escherichia coli isolates from human patients. These isolates had high MICs (32 to 256 μg/mL) for ciprofloxacin and contained point mutations in the quinolone resistance-determining region (QRDR) of both gyrA and parC that confer resistance to fluoroquinolone. The whole-genome sequence data provide a better understanding of the fluoroquinolone resistance mechanisms in these isolates and would be beneficial in source tracking these pathogens during pandemic outbreaks.

SUBMITTER: Alotaibi K

PROVIDER: S-EPMC9022563 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Draft Genome Sequences of Sixteen Fluoroquinolone-Resistant Extraintestinal Escherichia coli Isolates from Human Patients.

Alotaibi Khulud K Khan Ashraf A AA Marasa Bernard B Khan Saeed A SA Johnson James J Johnston Brian B Sung Kidon K Nawaz Mohamed M

Microbiology resource announcements 20220315 4

We report here the draft genome sequences of 16 fluoroquinolone-resistant extraintestinal Escherichia coli isolates from human patients. These isolates had high MICs (32 to 256 μg/mL) for ciprofloxacin and contained point mutations in the quinolone resistance-determining region (QRDR) of both <i>gyrA</i> and <i>parC</i> that confer resistance to fluoroquinolone. The whole-genome sequence data provide a better understanding of the fluoroquinolone resistance mechanisms in these isolates and would ...[more]

PMID: 35289649

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