The short-term effects of estradiol, raloxifene, and a phytoestrogen in women with perimenopausal depression.

ABSTRACT:

Objective

We examined the short-term efficacies of three estrogen-like compounds under placebo-controlled conditions in women with perimenopause-related depression (PMD).

Methods

Women with PMD were randomized in a double-blind parallel design to one of four treatments: transdermal 17-beta estradiol (TE) (100 mcg/d); oral raloxifene (60 mg/d); a proprietary phytoestrogen compound, Rimostil (1,000 mg twice/d); or placebo for 8 weeks. The main outcome measures were the Center for Epidemiology Studies Depression Scale, 17-item Hamilton Rating Scale for Depression (HRSD), and the Beck Depression Inventory completed at each clinic visit. Secondary outcomes included a visual analogue self-rating completed at each clinic visit, and daily self-ratings of hot flush severity. Cognitiv

SUBMITTER: Schmidt PJ 

PROVIDER: S-EPMC9022873 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature