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Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation.


ABSTRACT:

Objective

SARS-CoV-2 infection induces significant inflammatory cytokine production in adults, but infant cytokine signatures in pregnancies affected by maternal SARS-CoV-2 are less well characterized. We aimed to evaluate cytokine profiles of mothers and their infants following COVID-19 in pregnancy.

Study design

Serum samples at delivery from 31 mother-infant dyads with maternal SARS-CoV-2 infection in pregnancy (COVID) were examined in comparison to 29 control dyads (Control). Samples were evaluated using a 13-plex cytokine assay.

Results

In comparison with controls, interleukin (IL)-6 and interferon gamma-induced protein 10 (IP-10) were higher in COVID maternal and infant samples (p < 0.05) and IL-8 uniquely elevated in COVID infant samples (p < 0.05). Significant elevations in IL-6, IP-10, and IL-8 were found among both early (1st/2nd Trimester) and late (3rd Trimester) maternal SARS-CoV-2 infections.

Conclusions

Maternal SARS-CoV-2 infections throughout gestation are associated with increased maternal and infant inflammatory cytokines at birth with potential to impact long-term infant health.

SUBMITTER: Taglauer ES 

PROVIDER: S-EPMC9022897 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Publications

Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation.

Taglauer Elizabeth S ES   Dhole Yashoda Y   Boateng Jeffery J   Snyder-Cappione Jennifer J   Parker Samantha E SE   Clarke Katherine K   Juttukonda Lillian L   Devera Jean J   Hunnewell Jessica J   Barnett Elizabeth E   Jia Hongpeng H   Yarrington Christina C   Sabharwal Vishakha V   Wachman Elisha M EM  

Journal of perinatology : official journal of the California Perinatal Association 20220421 10


<h4>Objective</h4>SARS-CoV-2 infection induces significant inflammatory cytokine production in adults, but infant cytokine signatures in pregnancies affected by maternal SARS-CoV-2 are less well characterized. We aimed to evaluate cytokine profiles of mothers and their infants following COVID-19 in pregnancy.<h4>Study design</h4>Serum samples at delivery from 31 mother-infant dyads with maternal SARS-CoV-2 infection in pregnancy (COVID) were examined in comparison to 29 control dyads (Control).  ...[more]

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