Ontology highlight
ABSTRACT: Objective
SARS-CoV-2 infection induces significant inflammatory cytokine production in adults, but infant cytokine signatures in pregnancies affected by maternal SARS-CoV-2 are less well characterized. We aimed to evaluate cytokine profiles of mothers and their infants following COVID-19 in pregnancy.Study design
Serum samples at delivery from 31 mother-infant dyads with maternal SARS-CoV-2 infection in pregnancy (COVID) were examined in comparison to 29 control dyads (Control). Samples were evaluated using a 13-plex cytokine assay.Results
In comparison with controls, interleukin (IL)-6 and interferon gamma-induced protein 10 (IP-10) were higher in COVID maternal and infant samples (p < 0.05) and IL-8 uniquely elevated in COVID infant samples (p < 0.05). Significant elevations in IL-6, IP-10, and IL-8 were found among both early (1st/2nd Trimester) and late (3rd Trimester) maternal SARS-CoV-2 infections.Conclusions
Maternal SARS-CoV-2 infections throughout gestation are associated with increased maternal and infant inflammatory cytokines at birth with potential to impact long-term infant health.
SUBMITTER: Taglauer ES
PROVIDER: S-EPMC9022897 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Taglauer Elizabeth S ES Dhole Yashoda Y Boateng Jeffery J Snyder-Cappione Jennifer J Parker Samantha E SE Clarke Katherine K Juttukonda Lillian L Devera Jean J Hunnewell Jessica J Barnett Elizabeth E Jia Hongpeng H Yarrington Christina C Sabharwal Vishakha V Wachman Elisha M EM
Journal of perinatology : official journal of the California Perinatal Association 20220421 10
<h4>Objective</h4>SARS-CoV-2 infection induces significant inflammatory cytokine production in adults, but infant cytokine signatures in pregnancies affected by maternal SARS-CoV-2 are less well characterized. We aimed to evaluate cytokine profiles of mothers and their infants following COVID-19 in pregnancy.<h4>Study design</h4>Serum samples at delivery from 31 mother-infant dyads with maternal SARS-CoV-2 infection in pregnancy (COVID) were examined in comparison to 29 control dyads (Control). ...[more]