Nonmodular oscillator and switch based on RNA decay drive regeneration of multimodal gene expression.

ABSTRACT: Periodic gene expression dynamics are key to cell and organism physiology. Studies of oscillatory expression have focused on networks with intuitive regulatory negative feedback loops, leaving unknown whether other common biochemical reactions can produce oscillations. Oscillation and noise have been proposed to support mammalian progenitor cells' capacity to restore heterogenous, multimodal expression from extreme subpopulations, but underlying networks and specific roles of noise remained elusive. We use mass-action-based models to show that regulated RNA degradation involving as few as two RNA species-applicable to nearly half of human protein-coding genes-can generate sustained oscillations without explicit feedback. Diverging oscillation periods synergize with noise to robustly restor

SUBMITTER: Nordick B 

PROVIDER: S-EPMC9023291 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature