Humoral and cellular responses to spike of δ SARS-CoV-2 variant in vaccinated patients with immune-mediated inflammatory diseases.

ABSTRACT:

Objectives

We assessed vaccination-induced antibody and cellular responses against spike from the ancestral strain and from the delta (δ) SARS-CoV-2 variant in patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive therapy in comparison with immunocompetent subjects.

Methods

We enrolled patients with IMID and immunocompetent subjects who completed the vaccination schedule within 4-6 months from the first dose. The interferon (IFN)-γ-response to spike peptides that were derived from the ancestral and the δ SARS-CoV-2 were measured by ELISA. Anti-Receptor Binding Domain IgG antibodies were also evaluated.

Results

We enrolled 43 patients with IMID and nine immunocompetent subjects. No significant differences were found after comparing the specif

SUBMITTER: Petrone L 

PROVIDER: S-EPMC9023365 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature