Changes in neural processing and evaluation of negative facial expressions after administration of an open-label placebo.

ABSTRACT: A recent event-related potential (ERP) study found that an open-label placebo (OLP) reduced emotional distress during the viewing of unpleasant scenes and the amplitude of the late positive potential (LPP). The present ERP experiment aimed at a conceptual replication of this finding and investigated OLP effects during affective face processing. The participants (109 females) were presented with images depicting angry and neutral facial expressions after the administration of a saline nasal spray. The spray was either introduced as a placebo that could help reduce the emotional reactions to viewing angry faces (OLP group) or to improve the electrophysiological recordings (Control group). The OLP was associated with reduced LPP amplitudes (1000-6000 ms) to anger expressions across a frontal

SUBMITTER: Schienle A 

PROVIDER: S-EPMC9023441 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature