Golgi apparatus-targeted aggregation-induced emission luminogens for effective cancer photodynamic therapy.

ABSTRACT: Golgi apparatus (GA) oxidative stress induced by in situ reactive oxygen species (ROS) could severely damage the morphology and function of GA, which may open up an avenue for effective photodynamic therapy (PDT). However, due to the lack of effective design strategy, photosensitizers (PSs) with specific GA targeting ability are in high demand and yet quite challenging. Herein, we report an aggregation-induced emission luminogen (AIEgen) based PS (TPE-PyT-CPS) that can effectively target the GA via caveolin/raft mediated endocytosis with a Pearson correlation coefficient up to 0.98. Additionally, the introduction of pyrene into TPE-PyT-CPS can reduce the energy gap between the lowest singlet state (S₁) and the lowest triplet state (T₁) (ΔE_ST) and exhibits e

SUBMITTER: Liu M 

PROVIDER: S-EPMC9023483 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature