Primary tumour immune response and lymph node yields in colon cancer.

ABSTRACT:

Background

The mechanism underlying improved survival in non-metastatic colon cancer with higher lymph node (LN) yield is unknown. This study aimed to identify whether molecular features in the primary tumour were predictive of LN yield.

Methods

Clinical, genomic, transcriptomic, proteomic and methylation data of non-metastatic, colon cancers studied in The Cancer Genome Atlas were interrogated for associations with LN yield. Based on maximal survival effects, patients were segregated into high (>15) and low (≤15) LN yield. Gene set enrichment analysis was performed on transcriptomic changes to identify biological processes associated with LN yield. Correlations were validated in an independent set of Stage II colon cancers.

Results

High LN yield was found predictive

SUBMITTER: Lal N 

PROVIDER: S-EPMC9023574 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature