Altered functional brain dynamics in chromosome 22q11.2 deletion syndrome during facial affect processing.

ABSTRACT: Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a multisystem disorder associated with multiple congenital anomalies, variable medical features, and neurodevelopmental differences resulting in diverse psychiatric phenotypes, including marked deficits in facial memory and social cognition. Neuroimaging in individuals with 22q11.2DS has revealed differences relative to matched controls in BOLD fMRI activation during facial affect processing tasks. However, time-varying interactions between brain areas during facial affect processing have not yet been studied with BOLD fMRI in 22q11.2DS. We applied constrained principal component analysis to identify temporally overlapping brain activation patterns from BOLD fMRI data acquired during an emotion identification task from 58 individuals with

SUBMITTER: Cornblath EJ 

PROVIDER: S-EPMC9023602 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature