¹⁶⁶Holmium-^99mTechnetium dual-isotope imaging: scatter compensation and automatic healthy-liver segmentation for ¹⁶⁶Holmium radioembolization dosimetry.

ABSTRACT:

Background

Partition modeling allows personalized activity calculation for holmium-166 (¹⁶⁶Ho) radioembolization. However, it requires the definition of tumor and non-tumorous liver, by segmentation and registration of a separately acquired CT, which is time-consuming and prone to error. A protocol including ¹⁶⁶Ho-scout, for treatment simulation, and technetium-99m (^99mTc) stannous phytate for healthy-liver delineation was proposed. This study assessed the accuracy of automatic healthy-liver segmentation using ^99mTc images derived from a phantom experiment. In addition, together with data from a patient study, the effect of different ^99mTc activities on the ¹⁶⁶Ho-scout images was investigated. To reproduce a typical

SUBMITTER: Stella M 

PROVIDER: S-EPMC9023629 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature