More Than Just Statics: Temporal Dynamic Changes in Inter- and Intrahemispheric Functional Connectivity in First-Episode, Drug-Naive Patients With Major Depressive Disorder.

ABSTRACT: Several functional magnetic resonance imaging (fMRI) studies have demonstrated abnormalities in static intra- and interhemispheric functional connectivity among diverse brain regions in patients with major depressive disorder (MDD). However, the dynamic changes in intra- and interhemispheric functional connectivity patterns in patients with MDD remain unclear. Fifty-eight first-episode, drug-naive patients with MDD and 48 age-, sex-, and education level-matched healthy controls (HCs) underwent resting-state fMRI. Whole-brain functional connectivity, analyzed using the functional connectivity density (FCD) approach, was decomposed into ipsilateral and contralateral functional connectivity. We computed the intra- and interhemispheric dynamic FCD (dFCD) using a sliding window analysis to capt

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC9024080 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature