On the Relationship Between Pain Variability and Relief in Randomized Clinical Trials.

ABSTRACT: Previous research reports suggest greater baseline variability is associated with greater pain relief in those who receive a placebo. However, studies that evidence this association do not control for confounding effects from regression to the mean and natural history. In this report, we analyzed data from two randomized clinical trials (Placebo I and Placebo II, total N = 139) while adjusting for the effects of natural history and regression to the mean via a no treatment group. Results agree between the two placebo groups in each study: both placebo groups showed negligible semi-partial correlations between baseline variability and adjusted response [r _sp (CI_95%) = 0.22 (0.03, 0.42) and 0 (-0.07, 0.07) for Placebo I and II, respectively]. The no

SUBMITTER: Tiwari SR 

PROVIDER: S-EPMC9024103 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature