Association between proton pump inhibitor use and risk of pneumonia in children: nationwide self-controlled case series study in Sweden.

ABSTRACT:

Objective

To evaluate the association between use of proton pump inhibitors (PPIs) and risk of pneumonia in children.

Design

Nationwide register-based self-controlled case series study.

Setting

Sweden, July 2006 to December 2016.

Participants

Children aged <18 years who were treated with PPIs and had a hospitalisation or hospital emergency care visit for pneumonia within 1 year before and 2 years after PPI initiation.

Main outcomes and measures

The primary analysis examined the risk of pneumonia during the risk period (ongoing PPI treatment), the pre-exposure period (≤30 days preceding PPI treatment) and the postexposure period (days 1-365 after PPI discontinuation), comparing to the unexposed period. Conditional Poisson regression was used to estimate i

SUBMITTER: Wang YH 

PROVIDER: S-EPMC9024237 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature