Gene-Environment Interaction on Type 2 Diabetes Risk among Chinese Adults Born in Early 1960s.

ABSTRACT:

Background

Gene-environment interactions on type 2 diabetes (T2D) risk are studied little among Chinese adults.

Aim

This study aimed to explore the interactions among Chinese adults born in early 1960s.

Methods

The interaction of single nucleotide polymorphisms (SNPs) and environmental factors on T2D risk were analyzed by multiple linear or logistic regression models, and in total 2216 subjects were included with the age of 49.7 ± 1.5 years.

Results

High dietary intake increased the effects of rs340874 on impaired fasting glucose (IFG), rs5015480, rs7612463 on T2D (OR = 2.27, 2.37, 11.37, respectively), and reduced the effects of rs7172432 on IFG, rs459193 on impaired glucose tolerance (IGT) (OR = 0.08, 0.28, respectively). The associations between rs4607517 an

SUBMITTER: Song C 

PROVIDER: S-EPMC9024429 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature