Stereoselective Synthesis of β-Glycinamide Ribonucleotide.

ABSTRACT: A diastereoselective synthesis of the β-anomer of glycinamide ribonucleotide (β-GAR) has been developed. The synthesis was accomplished in nine steps from D-ribose and occurred in 5% overall yield. The route provided material on the multi-milligram scale. The synthetic β-GAR formed was remarkably resistant to anomerization both in solution and as a solid.

SUBMITTER: Ngu L 

PROVIDER: S-EPMC9024515 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature