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Stereoselective Synthesis of β-Glycinamide Ribonucleotide.

ABSTRACT: A diastereoselective synthesis of the β-anomer of glycinamide ribonucleotide (β-GAR) has been developed. The synthesis was accomplished in nine steps from D-ribose and occurred in 5% overall yield. The route provided material on the multi-milligram scale. The synthetic β-GAR formed was remarkably resistant to anomerization both in solution and as a solid.

SUBMITTER: Ngu L

PROVIDER: S-EPMC9024515 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Stereoselective Synthesis of β-Glycinamide Ribonucleotide.

Ngu Lisa L Ray Debarpita D Watson Samantha S SS Beuning Penny J PJ Ondrechen Mary Jo MJ O'Doherty George A GA

Molecules (Basel, Switzerland) 20220414 8

A diastereoselective synthesis of the β-anomer of glycinamide ribonucleotide (β-GAR) has been developed. The synthesis was accomplished in nine steps from D-ribose and occurred in 5% overall yield. The route provided material on the multi-milligram scale. The synthetic β-GAR formed was remarkably resistant to anomerization both in solution and as a solid. ...[more]

PMID: 35458726

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