Phage Therapy Potentiates Second-Line Antibiotic Treatment against Pneumonic Plague.

ABSTRACT: Plague pandemics and outbreaks have killed millions of people during the history of humankind. The disease, caused by the bacteria Yersinia pestis, is currently treated effectively with antibiotics. However, in the case of multidrug-resistant (MDR) bacteria, alternative treatments are required. Bacteriophage (phage) therapy has shown efficient antibacterial activity in various experimental animal models and in human patients infected with different MDR pathogens. Here, we evaluated the efficiency of фA1122 and PST phage therapy, alone or in combination with second-line antibiotics, using a well-established mouse model of pneumonic plague. Phage treatment significantly delayed mortality and limited bacterial proliferation in the lungs. However, the treatment did not prevent bacteremi

SUBMITTER: Vagima Y 

PROVIDER: S-EPMC9024586 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature