Combining Radiotherapy and Immunotherapy in Metastatic Breast Cancer: Current Status and Future Directions.

ABSTRACT: The role of radiotherapy and immunotherapy with immune checkpoint inhibitors (ICI) is of emerging interest in many solid tumours, including breast cancer. There is increasing evidence that the host's immune system plays an important role in influencing the response to treatment and prognosis in breast cancer. Several pre-clinical studies and clinical trials have reported on the 'abscopal effect-regression of distant untreated tumour sites, mediated by an immunological response following ionizing radiation to a targeted tumour site. Stereotactic Ablative Body Radiotherapy (SABR) is a non-invasive technique used to augment various immune responses with an ablative tumoricidal dose when compared to conventional radiotherapy. SABR is characterized by typically 1-5 precision radiotherapy treatm

SUBMITTER: David S 

PROVIDER: S-EPMC9024725 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature