Pharmacokinetics of DA-6886, A New 5-HT4 Receptor Agonist, in Rats.

ABSTRACT: DA-6886 is a novel serotonin (5-hydroxytrypamine [5-HT]) receptor 4 agonist for the potential treatment of constipation-predominant irritable bowel syndrome. The purpose of this study was to validate the quantitative assay of DA-6886 in rat plasma and to evaluate the pharmacokinetics and tissue distribution of DA-6886 in rats. The liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the robust quantification of DA-6886 in rat plasma was successfully validated and applied to the pharmacokinetic studies in rats. The pharmacokinetic parameters of DA-6886 in rats were evaluated following single intravenous or oral administration at three dose levels (2, 10, and 20 mg/kg). DA-6886 exhibited a smaller dose-normalized area under the plasma concentration-time curve (AUC) values and

SUBMITTER: Lee DY 

PROVIDER: S-EPMC9024849 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature