Plasma Polyamine Biomarker Panels: Agmatine in Support of Prostate Cancer Diagnosis.

ABSTRACT: Prostate cancer is the most frequent malignant tumour among males (19%), often clinically silent and of difficult prognosis. Although several studies have highlighted the diagnostic and prognostic role of circulating biomarkers, such as PSA, their measurement does not necessarily allow the detection of the disease. Within this context, many authors suggest that the evaluation of circulating polyamines could represent a valuable tool, although several analytical problems still counteract their clinical practice. In particular, agmatine seems particularly intriguing, being a potential inhibitor of polyamines commonly derived from arginine. The aim of the present work was to evaluate the potential role of agmatine as a suitable biomarker for the identification of different classes of patients

SUBMITTER: Coradduzza D 

PROVIDER: S-EPMC9024899 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature