B Cells Specific CpG Induces High IL-10 and IL-6 Expression In Vitro in Neuro-Behcet's Disease.

ABSTRACT: Remitting-RelapsingMultiple Sclerosis (RRMS) and Neuro-Behçet Disease (NBD) are two chronic neuroinflammatory disorders leading to neurological damage. Herein, we investigated in these patients the IL-10-producing cells during the early stages of these disorders. Cellular and molecular investigations were carried out on treatment naive patients suffering from RRMS and NBD recruited at the first episode of clinical relapse. Our findings demonstrate that CSF-B cells from NBD patients, but not RRMS, are the major source of intrathecal IL-10 as compared to T-CD4 cells. Moreover, we showed a lower expression of TGF-β and IL35, in the CSF cells of NBD patients as compared to the control group. Specific in vitro CpG stimulation of peripheral blood B cells from NBD patients resulted in a concomita

SUBMITTER: Maghrebi O 

PROVIDER: S-EPMC9025002 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature