Bladder Cancer Cells Exert Pleiotropic Effects on Human Adipose-Derived Stem Cells.

ABSTRACT: Stem cell-based therapies are considered one of the most promising disciplines in biomedicine. Bladder cancer patients could benefit from therapies directed to promote healing after invasive surgeries or to lessen urinary incontinence, a common side effect of both cancer itself and the treatment. However, the local delivery of cells producing large amounts of paracrine factors may alter interactions within the microenvironment. For this reason, reconstructive cellular therapies for patients with a history of cancer carry a potential risk of tumor reactivation. We used an indirect co-culture model to characterize the interplay between adipose-derived stem cells and bladder cancer cells. Incubation with ASCs increased MCP-1 secretion by bladder cancer cells (from 2.1-fold to 8.1-fold, depend

SUBMITTER: Maj M 

PROVIDER: S-EPMC9025060 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature