The Effect of Hypothermia and Osmotic Shock on the Electrocardiogram of Adult Zebrafish.

ABSTRACT: The use of zebrafish to explore cardiac physiology has been widely adopted within the scientific community. Whether this animal model can be used to determine drug cardiac toxicity via electrocardiogram (ECG) analysis is still an ongoing question. Several reports indicate that the recording configuration severely affects the ECG waveforms and its derived-parameters, emphasizing the need for improved characterization. To address this problem, we recorded ECGs from adult zebrafish hearts in three different configurations (unexposed heart, exposed heart, and extracted heart) to identify the most reliable method to explore ECG recordings at baseline and in response to commonly used clinical therapies. We found that the exposed heart configuration provided the most reliable and reproducible ECG

SUBMITTER: Arel E 

PROVIDER: S-EPMC9025276 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature