Endoglin and Other Angiogenesis Markers in Recurrent Varicose Veins.

ABSTRACT:

Background

Surgery on varicose veins (crossectomy and stripping) may lead to recurrence, with clinical and socioeconomic repercussions. The etiopathogenesis of varicose veins has yet to be fully understood.

Objective

Study the expression of endoglin and other molecules involved in the neovascularisation process in patients suffering from this disease.

Methods

Total of 43 patients that have undergone surgery for varicose veins (24 primary and 19 recurrent). Endoglin and other molecules were identified on the venous wall (proximal -saphenofemoral junction- and distal), via real-time RT-PCR, and in serum, via ELISA: endoglin (Eng), vascular endothelial growth factor (VEGF-A), its receptors 1 and 2 (VEGFR1 or FLT1), (VEGFR2 or FLK), and the hypoxia-inducible factor (HIF-1

SUBMITTER: Sanchez FSL 

PROVIDER: S-EPMC9025299 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature