Fabrication and Modelling of a Reservoir-Based Drug Delivery System for Customizable Release.

ABSTRACT: Localized therapy approaches have emerged as an alternative drug administration route to overcome the limitations of systemic therapies, such as the crossing of the blood-brain barrier in the case of brain tumor treatment. For this, implantable drug delivery systems (DDS) have been developed and extensively researched. However, to achieve an effective localized treatment, the release kinetics of DDS needs to be controlled in a defined manner, so that the concentration at the tumor site is within the therapeutic window. Thus, a DDS, with patient-specific release kinetics, is crucial for the improvement of therapy. Here, we present a computationally supported reservoir-based DDS (rDDS) development towards patient-specific release kinetics. The rDDS consists of a reservoir surrounded by a pol

SUBMITTER: Hauck M 

PROVIDER: S-EPMC9025308 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature