The Role of Systemic Filtrating Organs in Aging and Their Potential in Rejuvenation Strategies.

ABSTRACT: Advances in aging studies brought about by heterochronic parabiosis suggest that agingmight be a reversable process that is affected by changes in the systemic milieu of organs andcells. Given the broadness of such a systemic approach, research to date has mainly questioned theinvolvement of "shared organs" versus "circulating factors". However, in the absence of a clearunderstanding of the chronological development of aging and a unified platform to evaluate thesuccesses claimed by specific rejuvenation methods, current literature on this topic remains scattered.Herein, aging is assessed from an engineering standpoint to isolate possible aging potentiators via ajuxtaposition between biological and mechanical systems. Such a simplification provides a generalframework for future research in

SUBMITTER: Kassab A 

PROVIDER: S-EPMC9025381 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature