Effects of Soy-Based Infant Formula on Weight Gain and Neurodevelopment in an Autism Mouse Model.

ABSTRACT: Mice fed soy-based diets exhibit increased weight gain compared to mice fed casein-based diets, and the effects are more pronounced in a model of fragile X syndrome (FXS; Fmr1^KO). FXS is a neurodevelopmental disability characterized by intellectual impairment, seizures, autistic behavior, anxiety, and obesity. Here, we analyzed body weight as a function of mouse age, diet, and genotype to determine the effect of diet (soy, casein, and grain-based) on weight gain. We also assessed plasma protein biomarker expression and behavior in response to diet. Juvenile Fmr1^KO mice fed a soy protein-based rodent chow throughout gestation and postnatal development exhibit increased weight gain compared to mice fed a casein-based purified ingredient diet or grain-based

SUBMITTER: Westmark CJ 

PROVIDER: S-EPMC9025435 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature