A Comparison of Evans Blue and 4-(p-Iodophenyl)butyryl Albumin Binding Moieties on an Integrin α_vβ₆ Binding Peptide.

ABSTRACT: Serum albumin binding moieties (ABMs) such as the Evans blue (EB) dye fragment and the 4-(p-iodophenyl)butyryl (IP) have been used to improve the pharmacokinetic profile of many radiopharmaceuticals. The goal of this work was to directly compare these two ABMs when conjugated to an integrin α_vβ₆ binding peptide (α_vβ₆-BP); a peptide that is currently being used for positron emission tomography (PET) imaging in patients with metastatic cancer. The ABM-modified α_vβ₆-BP peptides were synthesized with a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracetic acid (DOTA) chelator for radiolabeling with copper-64 to yield [⁶⁴Cu]Cu DOTA-EB-α_vβ₆-BP ([⁶⁴Cu]1) and [⁶⁴Cu]Cu

SUBMITTER: Davis RA 

PROVIDER: S-EPMC9025560 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature