A Theranostic Nanocomplex Combining with Magnetic Hyperthermia for Enhanced Accumulation and Efficacy of pH-Triggering Polymeric Cisplatin(IV) Prodrugs.

ABSTRACT: Although polymeric platinum(IV) (Pt(IV)) prodrugs can reduce the side effects of cisplatin, the efficacy of the prodrug is still limited by its non-targeted distribution, poor penetration in deep tumor tissue, and low cytotoxicity in tumor cells. To improve the clinical potential of polymeric prodrug micelle, we synthesized amphiphilic polymeric Pt(IV) with high Pt content (22.5%), then developed a theranostic nanocomplex by integrating polymeric Pt(IV) with superparamagnetic Mn_0.6Zn_0.4Fe₂O₄ via simple self-assembly. Due to the high content of Mn_0.6Zn_0.4Fe₂O₄ (41.7% w/w), the theranostic nanocomplex showed high saturation magnetization (103.1 emu g^-1) and excellent magnetocalori

SUBMITTER: Qu Y 

PROVIDER: S-EPMC9025582 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature