Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ_25-35-Induced Mice by Inhibiting the NLRP3 Inflammasome.

ABSTRACT: (1) Alzheimer's disease (AD) is a neurodegenerative disorder, and it is now widely accepted that neuroinflammation plays a key role in its pathogenesis. Eriodictyol (Eri) and homoeriodictyol (Hom), dihydroflavonoids extracted from a variety of plants, have been confirmed to display a relationship with neuroprotection. (2) Methods: An AD mouse model was constructed by intracerebroventricular (ICV) injection of the Aβ_25-35 peptide, and Eri and Hom were administered orally for 4 weeks. UPLC-MS/MS was used to determine whether Eri and Hom cross the blood-brain barrier to exert their therapeutic effects. Histological changes in the brain and levels of Aβ were evaluated, and Y-maze and new object recognition experiments were conducted to assess the effects of Eri and Hom on Aβ_25-

SUBMITTER: Guo P 

PROVIDER: S-EPMC9025671 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature