Reciprocal Regulation of Shh Trafficking and H₂O₂ Levels via a Noncanonical BOC-Rac1 Pathway.

ABSTRACT: Among molecules that bridge environment, cell metabolism, and cell signaling, hydrogen peroxide (H₂O₂) recently appeared as an emerging but central player. Its level depends on cell metabolism and environment and was recently shown to play key roles during embryogenesis, contrasting with its long-established role in disease progression. We decided to explore whether the secreted morphogen Sonic hedgehog (Shh), known to be essential in a variety of biological processes ranging from embryonic development to adult tissue homeostasis and cancers, was part of these interactions. Here, we report that H₂O₂ levels control key steps of Shh delivery in cell culture: increased levels reduce primary secretion, stimulate endocytosis and accelerate delivery to

SUBMITTER: Thauvin M 

PROVIDER: S-EPMC9025708 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature