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Methodologies for the De novo Discovery of Transposable Element Families.

ABSTRACT: The discovery and characterization of transposable element (TE) families are crucial tasks in the process of genome annotation. Careful curation of TE libraries for each organism is necessary as each has been exposed to a unique and often complex set of TE families. De novo methods have been developed; however, a fully automated and accurate approach to the development of complete libraries remains elusive. In this review, we cover established methods and recent developments in de novo TE analysis. We also present various methodologies used to assess these tools and discuss opportunities for further advancement of the field.

SUBMITTER: Storer JM

PROVIDER: S-EPMC9025800 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Methodologies for the De novo Discovery of Transposable Element Families.

Storer Jessica M JM Hubley Robert R Rosen Jeb J Smit Arian F A AFA

Genes 20220417 4

The discovery and characterization of transposable element (TE) families are crucial tasks in the process of genome annotation. Careful curation of TE libraries for each organism is necessary as each has been exposed to a unique and often complex set of TE families. De novo methods have been developed; however, a fully automated and accurate approach to the development of complete libraries remains elusive. In this review, we cover established methods and recent developments in de novo ...[more]

PMID: 35456515

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