The Role of Propranolol as a Repurposed Drug in Rare Vascular Diseases.

ABSTRACT: Rare Diseases (RD) are defined by their prevalence in less than 5 in 10,000 of the general population. Considered individually, each RD may seem insignificant, but together they add up to more than 7000 different diseases. Research in RD is not attractive for pharmaceutical companies since it is unlikely to recover development costs for medicines aimed to small numbers of patients. Since most of these diseases are life threatening, this fact underscores the urgent need for treatments. Drug repurposing consists of identifying new uses for approved drugs outside the scope of the original medical indication. It is an alternative option in drug development and represents a viable and risk-managed strategy to develop for RDs. In 2008, the "off label" therapeutic benefits of propranolol were des

SUBMITTER: Cuesta AM 

PROVIDER: S-EPMC9025921 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature