Superstructure Detection in Nucleosome Distribution Shows Common Pattern within a Chromosome and within the Genome.

ABSTRACT: Nucleosome positioning plays an important role in crucial biological processes such as replication, transcription, and gene regulation. It has been widely used to predict the genome's function and chromatin organisation. So far, the studies of patterns in nucleosome positioning have been limited to transcription start sites, CTCFs binding sites, and some promoter and loci regions. The genome-wide organisational pattern remains unknown. We have developed a theoretical model to coarse-grain nucleosome positioning data in order to obtain patterns in their distribution. Using hierarchical clustering on the auto-correlation function of this coarse-grained nucleosome positioning data, a genome-wide clustering is obtained for Candida albicans. The clustering shows the existence beyond hete

SUBMITTER: Mishra SK 

PROVIDER: S-EPMC9026121 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature