Novel directions of precision oncology: circulating microbial DNA emerging in cancer-microbiome areas.

ABSTRACT: Microbiome research has extended into the cancer area in the past decades. Microbes can affect oncogenesis, progression, and treatment response through various mechanisms, including direct regulation and indirect impacts. Microbiota-associated detection methods and agents have been developed to facilitate cancer diagnosis and therapy. Additionally, the cancer microbiome has recently been redefined. The identification of intra-tumoral microbes and cancer-related circulating microbial DNA (cmDNA) has promoted novel research in the cancer-microbiome area. In this review, we define the human system of commensal microbes and the cancer microbiome from a brand-new perspective and emphasize the potential value of cmDNA as a promising biomarker in cancer liquid biopsy. We outline all existing stud

SUBMITTER: You L 

PROVIDER: S-EPMC9026200 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature