Characterization of Tuna Gelatin-Based Hydrogels as a Matrix for Drug Delivery.

ABSTRACT: The skin of yellowfin tuna is one of the fishery industry solid residues with the greatest potential to add extra value to its circular economy that remains yet unexploited. Particularly, the high collagen content of fish skin allows generating gelatin by hydrolysis, which is ideal for forming hydrogels due to its biocompatibility and gelling capability. Hydrogels have been used as drug carriers for local administration due to their mechanical properties and drug loading capacity. Herein, novel tuna gelatin hydrogels were designed as drug vehicles with two structurally different antitumoral model compounds such as Doxorubicin and Crocin to be administrated locally in tissues with complex human anatomies after surgical resection. The characterization by gel permeation chromatography (GPC) o

SUBMITTER: Hermida-Merino C 

PROVIDER: S-EPMC9026235 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature