Angiogenic T Cells: Potential Biomarkers for the Early Diagnosis of Interstitial Lung Disease in Autoimmune Diseases?

ABSTRACT: (1) Background: We explored, for the first time, the contribution of angiogenic T cells (TAng) in interstitial lung disease associated to autoimmune disease (AD-ILD⁺) as potential biomarkers of the disease, evaluating their role in the underlying vasculopathy and lung fibrosis. Additionally, the relationship of TAng with clinical manifestations and cellular and molecular endothelial dysfunction-related biomarkers was assessed. (2) Methods: We included 57 AD-ILD⁺ patients (21 with rheumatoid arthritis (RA)-ILD⁺, 21 with systemic sclerosis (SSc)-ILD⁺ and 15 with other AD-ILD⁺) and three comparative groups: 45 AD-ILD^- patients (25 RA-ILD^- and 20 SSc-ILD^-); 21 idiopathic pulmonary fibrosis (IPF) patients; 2

SUBMITTER: Pulito-Cueto V 

PROVIDER: S-EPMC9026324 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature