Trehalose-Based Nucleolipids as Nanocarriers for Autophagy Modulation: An In Vitro Study.

ABSTRACT: The Autophagy Lysosomal Pathway is one of the most important mechanisms for removing dysfunctional cellular components. Increasing evidence suggests that alterations in this pathway play a pathogenic role in Parkinson's disease, making it a point of particular vulnerability. Numerous studies have proposed nanotechnologies as a promising approach for delivering active substances within the central nervous system to treat and diagnose neurodegenerative diseases. In this context, the aim was to propose the development of a new pharmaceutical technology for the treatment of neurodegenerative diseases. We designed a trehalose-based nanosystem by combining both a small natural autophagy enhancer molecule named trehalose and an amphiphilic nucleolipid conjugate. To improve nucleolipid protection

SUBMITTER: Cunha A 

PROVIDER: S-EPMC9026460 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature